From Wheatley to the John Radcliffe Hospital.  Uses the Old Road across Shotover.  Long, steady climb from Wheatley.  Very steep climb from Oxford if doing the route in the opposite direction.  Over Shotover the route is gravel, often pot-holed, difficult in wet weather and unlit (so probably only a daytime route for most people).  On the other hand this is definitely the most beautiful way to enter Oxford from the east, and one that has very little traffic across most of its route.

A purely utilitarian route from Wheatley to the John Radcliffe Hospital using the cycle path alongside the A40.  Much less fun than the alternative route via Shotover, but much flatter and probably to be preferred at night (despite problems being dazzled by headlights on this route if travelling towards Oxford in the dark).  Once you reach the Green Road roundabout a number of alternative routes to the JR are possible: the one shown is quiet and relatively safe from traffic, but it does cross Bury Knowle Park, which is unlit, so alternative routes are likely to be preferred at night.